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Researcher's Directory Results
::ACC member information updater::
| Ablin,Richard | ![]() |
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| Cancer Metastasis | ||
| Interim Director, Graduate Education Program, Immunobiology, Ph.D. | ||
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Address: Dept. of Immunobiology P.O. Box 245049 Work Phone: 520-626-7755 Fax Number: 520-626-2100 Email: mailto:ablinrj@email.arizona.edu |
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Biography: Prior to joining the Arizona Cancer Center and the University of Arizona College of Medicine, Dr. Ablin served consecutively as Director, Scientific Investigation at Tetragenex Pharmaceuticals, Inc. (Park Ridge, NJ), and Director, Immunobiology Unit, Department of Urology and Research Associate Professor of Urology, State University of New York at Stony Brook School of Medicine. He is President of the Robert Benjamin Ablin Foundation for Cancer Research, founded in memory of his father, since 1979. Dr. Ablin received his Ph.D. in Microbiology from the State University of New York at Buffalo in 1967, following which he continued his training in immunology as a United States Public Health Service Postdoctoral Fellow at the Medical School under the late renowned Distinguished Professor Ernest Witebsky. Dr. Ablin recently received the degree of D.Sc., honoris causa, from Lake Forest College, his undergraduate alma mater. Dr. Ablin discovered prostate-specific antigen (PSA) in 1970, for which he was a nominee for the Lasker Award in 1997. His discovery of PSA led to the development of the PSA test. A pioneer of cryosurgery and the concept of “cryoimmunotherapy” for the treatment of cancer, Dr. Ablin has extensive experience in cancer research, particularly in the study of the development and metastasis of cancer. A member of Phi Beta Kappa and various professional societies, including the American Association for Cancer Research, the American Association of Immunologists, the British Association of Surgical Oncology, the New York Academy of Sciences, and Sigma Xi, he was a founding member and Vice President (1977-80) of the American College of Cryosurgery and served as President (1977-80) of the International Society of Cryosurgery, who named him Honorary Life-Time President in 1980. Dr. Ablin is a Diplomat of the American Board of Clinical Immunology and Allergy and certified by the American Academy of Microbiology in Public Health and Medical Laboratory Microbiology. Cited in several biographical references, including American Men and Women of Science, Who's Who of Emerging Leaders in America and Who's Who in the World, he has been an invited speaker at numerous national and international scientific meetings and has contributed numerous articles to professional journals and texts. Dr. Ablin is co-editor of the book series Cancer Metastasis - Biology and Treatment and serves on the editorial board of several journals, including Clinical and Diagnostic Laboratory Immunology , Current Opinion in Oncology , Experimental Biology and Medicine , International Journal of Oncology and UroOncology . |
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Summary of Research Activity: Studies are directed toward: a) ascertaining the role of the inter- and/or intratumoural microenvironment (milieu) in contributing to the development and progression of cancer; b) the differentiation of latent (indolent) cancer from one that is aggrressive and clinically important and should be treated and c) development of response criteria (biological markers) to evaluate the effectiveness of new therapeutic regimens and/or agents for cancer. |
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Selected Publications:
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Collaborative Research:
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| Adam,Rodney | ![]() |
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| Non-Program Aligned | ||
| Professor, M.D. | ||
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Address: Dept. of Immunobiology PO BOX 245049 - AHSC Work Phone: 520-626-6887 Fax Number: 520-626-2100 Email: mailto:adamr@u.arizona.edu |
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Biography: |
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Summary of Research Activity: Mechanism of Antigenic Variation in Giardia lamblia and control of VSP expression - G. lamblia trophozoites undergo antigenic variation of a major surface antigen (VSPs). This antigenic variation may explain the chronicity of Giardia infections as well as the ability of trophozoites to infect the intestines of multiple different mammals. The focus of my laboratory has been to determine the molecular mechanism by which antigenic variation occurs and how VSP expression is controlled. The Genetics of Giardia lamblia - Giardia trophozoites are fairly unique in their possession of two nuclei, which are equivalent by all criteria that have been examined to date. Current evidence from my laboratory and others suggests that the trophozoites are tetraploid, each made up of two diploid nuclei, and that they reproduce asexually. We have developed a DNA:DNA fluorescence in situ hybridization (FISH) to examine similarities and differences between the nuclei. Giardia genome project - As part of a multi-center project funded by the NIH, we are determining the sequence of the Giardia genome. Our work has included analysis of the vsp genes, RNA polymerase genes, and the histone modification enzymes (acetylase, deacetylase, methylase, and kinase). This work will also help us to develop a better molecular classification system for Giardia. Mechanism of Antigenic Variation in Giardia lamblia and control of VSP expression - G. lamblia trophozoites undergo antigenic variation of a major surface antigen (VSPs). This antigenic variation may explain the chronicity of Giardia infections as well as the ability of trophozoites to infect the intestines of multiple different mammals. The focus of my laboratory has been to determine the molecular mechanism by which antigenic variation occurs and how VSP expression is controlled. The Genetics of Giardia lamblia - Giardia trophozoites are fairly unique in their possession of two nuclei, which are equivalent by all criteria that have been examined to date. Current evidence from my laboratory and others suggests that the trophozoites are tetraploid, each made up of two diploid nuclei, and that they reproduce asexually. We have developed a DNA:DNA fluorescence in situ hybridization (FISH) to examine similarities and differences between the nuclei. Giardia genome project - As part of a multi-center project funded by the NIH, we are determining the sequence of the Giardia genome. Our work has included analysis of the vsp genes, RNA polymerase genes, and the histone modification enzymes (acetylase, deacetylase, methylase, and kinase). This work will also help us to develop a better molecular classification system for Giardia. | ||