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Villar,Hugo Professor,M.D. GI Cancer
Address: SURGERY/ONCOLOGY -1968k - AZCC PO BOX 245024 - AZCC Work Phone: Fax Number: Email: mailto:hvillar@azcc.arizona.edu
Biography: Education MD: 1964, Universidad Catolica de Chile, Santiago, Chile Residencies: 1964-67 Universidad Catolica de Chile 1970-73 University of Texas Medical Branch, Galveston, TX 1973-74, Chief Resident, University of Texas Medical Branch, Galveston, TX Fellowships: 1967-70 Research, Dept. of Surgery, University of San Diego, CA 1973; Endoscopy Training, Bispebjerg Hospital, Copenhagen, Denmark 1976; Endoscopy Training, University Hospital, Erlangen, West Germany 1989; Intraoperative Radiation Therapy, Centre Leon Berard, Lyon, France Clinical Specialties Surgical Oncology Intraoperative Radiation Therapy Esophageal, Pancreatic, Rectal and Breast Cancers Board Certifications American Board of Surgery, 1976, Re-certified, 1990, 1999
Summary of Research Activity: A clinical protocol assessing the role of a large, single dose of radiation delivered at the time of surgery has been researched in conjunction with the Department of Radiation Oncology. Using Siemens 300 KV orothovoltage machine installed in one of the operating rooms, we administer a boost of radiation at the time of the local excision of the tumor. At present, 89 patients have been treated using this method. Most of them have had colorectal cancer and sarcomas, as well as pancreatic cancer. Initial results show no increase in survival when the group was compared with matched patients taken from the state registry in Phoenix. A striking lack of local complications, by keeping the total external beam of the radiation dose low, is perhaps the main advantage of this treatment. In addition, a non-concurrent cohort study to compare treatment outcomes, survival and total patient charges in 132 esophageal cancer patients treated from 1988 through 1999 looked at surgical, non-surgical and combined management. Combination therapy offers increased survival time, compared with surgery alone, at no appreciable increase in charges, but with significant increases in delayed complications. Chemoradiation therapy, without surgery, offers a substantial decrease in immediate complications and total hospital charges. However, this group has a lower survival time, likely due to a later stage at diagnosis. Surgical resection provided excellent palliation of dysphagia, regardless of additional therapy. Overall survival continues to be poor. All available therapies have risks of complications, considerable patient side effects and substantial expense.
Selected Publications: Warneke J, Berger R, Villar H, Stea D. Lumpectomy and Radiation Treatment for Invasive Lobular Carcinoma of the Breast. American Journal of Surgery 172(5)496, 1996. Heindl LM, Warneke JA, Hunter GC, Villar HV, Rappaport WD. One Institution's Ten Year Experience with Papillary Carcinoma of the Breast. Submitted to Journal American College of Surgeons, 1996. Dahn KA, Aldridge AJ, Warneke JA, Porter SL, Villar HV. Residual Breast Carcinoma at Re-excision for Breast Conservation. Submitted to American Journal of Surgery, 1997. Book Chapters Villar HV. Benign and Malignant Tumors of the Esophagus. Gastroenterology Text. J. Valenzuela (ed.) English and Spanish, 1997. Villar HV. Role of the Surgeon in the Diagnosis and Management of Lymphomas. Surgical Oncology. J. Arrastoa (ed.) English and Spanish, 1997.
Collaborative Research: H. Villar, C. Trout, J. Anderson, M. Lobell, J. Warneke, K. Harrigill, Department of Surgery, Surgical, Radiation and Medical Oncology, Arizona Cancer Center-Arizona Health Sciences Center, Tucson, Arizona: esophageal cancer: a comparison of surgical, non-surgical, and combined management.
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