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| Hatch,Kenneth Professor & Chairman,M.D. Cancer Prevention |
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| Address: OBSTETRICS & GYNECOLOGY - Room 8408 PO BOX 245078 - AZCC Work Phone: 520-626-6042 Fax Number: 520-626-2514 Email: mailto:khatch@u.arizona.edu |
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Biography:
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| Summary of Research Activity: Early detection and prevention of cervical cancer has been the main area of research for Dr. Hatch. Upon his arrival at the Arizona Cancer Center in 1990, he established a laboratory and clinical research group investigating the Human Papillomavirus (HPV) in Pap smear samples from young women in Pima County and across the border in Sonora, Mexico. The results of this research and that of hundreds of other investigators around the world have established that Human Papillomavirus is the causative agent of cervical cancer. The next step was to develop a vaccine against this virus. Two pharmaceutical companies have developed a vaccine. Clinical trials with the vaccine against HPV 6, 11, 16, and 18 have been conducted at the Arizona Cancer Center with Dr. Hatch as the Clinical Director for the past 5 years. The results show protection against both persistent infection of HPV as well as protection from abnormal Pap smears in the vaccine group versus the placebo. This protection has been observed up to 40 months and the clinical trials are continuing with Dr. Hatch as the principal investigator. The vaccine is undergoing licensing hearings at the Food and Drug Administration (FDA). It may become available within the next 1 to 2 years. The Arizona Cancer Center will again be a leader in establishing immunization programs that will be necessary to eliminate cervical cancer in our lifetime. His other area of interest is in improving surgical therapies for women with gynecologic cancer. Dr. Hatch was a pioneer in developing laparoscopic techniques (minimally invasive surgery) for gynecologic cancers and now it is a well established technique. It eliminates the need for large incisions, has less blood transfusions, shortens hospital stays to an average of 2 days and allows rapid return to full activity. Over 200 hundred gynecologic oncologist surgeons have been trained in this technique at the University of Arizona. For young women with cervical cancer who desire future childbearing, laparoscopic surgery can often be used to preserve her fertility. Arizona is one of only a few centers in the world performing this surgery and has reported three pregnancies in seventeen patients. At the other end of the age spectrum, laparoscopic surgery can be used on women whose health will not allow major operations.
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| Selected Publications:
• Giuliano A, Papenfuss M, Nour M, Canfield L, Schneider A, Hatch KD. Antioxidant nutrients: associations with persistent human papillomavirus infection. Cancer Epidemiol Biomark Prev 6:216-222, 1997. • Hatch KD, Nour M, Schneider A.. An evaluation of human papillomavirus testing for intermediate and high risk types as triage prior to colposcopy. Am J Obstet Gynecol 172:1150-1157, 1995. • KimYI, Mason JB, Giuliano A, Nour M, Selhub J, Hatch K, Schneider A, Rosenberg IH. Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma. Cancer 74:893-899, 1994.
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| Collaborative Research: |
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