Arizona Cancer Center :: Members' Directory::Results

Chambers,Setsuko Professor, Director of Women's Cancers,M.D. Cancer Metastasis
Address: Division of Women's Cancers PO Box 245024 - AZCC Work Phone: 520-626-0950 Fax Number: 520-626-8574 Email: mailto:schambers@azcc.arizona.edu
Biography: Dr. Chambers received her BS and MD degrees from Brown University. She completed her residency in Obstetrics and Gynecology as well as a fellowship in Gynecologic Oncology at Yale University. She remained at Yale as a member of the faculty until 2004. During her tenure at Yale, she was Director of the Gynecologic Oncology fellowship program and, until recently, was the only woman professor in Obstetrics and Gynecology. Throughout her career, Dr. Chambers has served on many national and regional committees, grant review panels and study sections. She is an examiner for the American Board of Obstetricians and Gynecologists and has served as President of the New England Association of Gynecologic Oncologists. She has authored over 80 peer reviewed publications and chapters. Dr. Chambers is one of the few gynecologic oncologist physician-scientists in the country, active as both a researcher and clinical gynecologic oncologist, evaluating oncology patients at the Arizona Cancer Center, an affiliate of the University Medical Center, University Physicians, Inc., and the University of Arizona. Her research laboratory, which is funded by both the National Cancer Institute and Department of Defense, is devoted to understanding the molecular basis for breast and ovarian cancer invasion and metastasis. Dr. Chambers recently moved to Tucson, Arizona to become Director of the newly-created Division of Women's Cancers at the Arizona Cancer Center. Her current role is to develop a comprehensive Women's Cancers program, encompassing both research and clinical practice in the areas of breast and gynecologic cancers. Her multidisciplinary division is comprised of gynecologic oncologists, surgical oncologists, medical oncologists, radiation oncologists, and translational and basic science researchers. Collectively, these experts seek to deliver exemplary, cutting-edge care to women throughout the Southwest who either have cancer or are at risk for developing this disease. Now, with the help of Christine and Lute Olson, it is likely that her vision will be realized.
Summary of Research Activity: • CSF-1 and its role in neoplastic progression of breast and ovarian cancer. • Androgens and neoplastic transformation of normal ovarian surface epithelium. • The c-fms proto-oncogene and breast cancer invasiveness.
Selected Publications: Chambers SK , Kacinski BM, Ivins CM, Carcangiu ML. Overexpression of epithelial CSF-1 and CSF-1 receptor: a poor prognostic factor in epithelial ovarian cancer; contrasted to a protective effect of stromal CSF-1. Clin Cancer Res. 1997;3:999-1007. Chambers SK, Chambers JT, Schwartz PE , Kohorn EI, Lorber MI, Handschumacher RE, Pizzorno G. Pharmacokinetic and phase I trial of intraperitoneal carboplatin and cyclosporine A in refractory gynecologic cancer patients. J Clin Oncol. 1997;15:1945-1952. Chambers SK , Ivins CM, Kacinski BM, Hochberg RB. An unexpected effect of glucocorticoids on stimulation of c-fms proto-oncogene expression in choriocarcinoma cells expressing little glucocorticoid receptor. Am J Obstet Gynecol. 2004;190:974-85. Tangir J, Bonafe N, Gilmore-Hebert M, Chambers SK . SGK-1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21:477-483. Toy EP, Bonafe N, Savlu A, Zeiss C, Zheng W, Flick M, Chambers SK . Correlation of tumor phenotype with c-fms proto-oncogene expression in an in vivo intraperitoneal model for experimental human breast cancer metastasis. Clin Exp Metastasis. 2005;22(1):1-9. Bonafe N, Gilmore-Hebert M, Folk NL, Azoudi M, Zhou Y, Chambers SK . Gyceraldehyde-3-Phosphate dehydrogenase binds to the AU-rich 3 ¢ untranslated region of colony-stimulating factor-1 messenger RNA in human ovarian cancer cells: possible role in colony-stimulating factor-1 posttranscriptional regulation and tumor phenotype. Cancer Res. 2005 May 1;65(9):3762-3771. Chambers SK . Systematic lymphadenectomy in advanced epithelial ovarian cancer: two decades of uncertainty resolved. J Natl Cancer Ins. 2005; 97(8):548-549.
Collaborative Research: Collaborative work with Roy R. Parker, PhD, Regents Professor and Howard Hughes Investigator, Molecular and Cell Biology, University of Arizona, Joan A. Steitz, PhD, Sterling Professor of Molecular Biophysics and Biochemistry, Yale University, and Imed Gallouzi, PhD, Assistant Professor, Biochemistry, McGill University on post-transcriptional gene regulation, 3' UTR RNA binding proteins. Collaborative work with Wenxin Zheng, MD, Professor of Pathology, Director of Molecular Pathology, now at University of Arizona, on the molecular pathogenesis of uterine papillary serous carcinoma, and on the hormonal etiology of ovarian cancer.
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