Cancer Prevention and Control Postdoctoral Fellowship

Summary | History | Goals | Director | Mentors | Research | Training | Application

Goals

The CPC Research Program seeks to develop and implement hypothesis-driven translational and basic science research studies related to cancer prevention and control which incorporate one or more of the following specific aims:

1. To develop new cancer chemopreventive agents and perform preclinical toxicology studies.
2. To identify promising preventive interventions (i.e., chemopreventive agents and nutritional interventions); to test the efficacy and mechanisms of these preventive interventions against cancer and intermediate cancer endpoints (e.g., actinic keratoses, adenomatous and hyperplastic colorectal polyps, prostatic intraepithelial neoplasia, and human papilloma virus persistence); and to facilitate the appropriate use of intermediate endpoints in cancer epidemiology and prevention research.
   
3. To investigate the molecular, genetic, phenotypic, biochemical, and immunologic alterations associated with carcinogenesis, and to support the application of these results to molecular epidemiologic cancer research.
4. To investigate the effect of chemopreventive agents on the carcinogenesis process as represented by molecular, phenotypic, biochemical, and immunologic markers.
   

In addition, the program seeks to develop and conduct clinical and population-based epidemiologic cancer prevention and control research studies that incorporate one or more of the following specific aims:

1. To identify and recruit high-risk subjects and minority populations in the Southwest, particularly southern Arizona, northern Mexico, the Phoenix metropolitan area, and the Native American reservations within Arizona, for cancer prevention studies.
2. To identify risk factors (e.g., environment, nutrition, physical activity) based on ongoing etiologic research, and to assess the relationship of these risk factors to cancer development. This is accomplished by translating research on intermediate cancer endpoints, and molecular, genetic, biochemical, and immunologic changes into strategies that can be used appropriately in an epidemiologic context.
3. To develop programs to decrease cancer incidence, increase cancer survival, and increase knowledge and practice of cancer screening practices among Hispanic and Native American populations within the Southwest.
4. To establish statewide networks of oncologists, surgeons, gastroenterologists, gynecologists, urologists, and dermatologists to facilitate cancer prevention clinical research.

The broader scientific goals of the CPC Program are directed at reducing the incidence, morbidity, and mortality of the major cancers (e.g., lung, colon, prostate, breast, skin, ovarian, endometrial, and cervical cancers).

 

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