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Immunology of tumor rejection and gene therapy of cancer
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Novel anti-cancer and chemoprevention drug development; chemoprevention of breast, colon, cervix, skin and prostate cancer; development, validation and testing of endpoint biomarkers for chemoprevention with special emphasis on quantitative histopathology using machine vision
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DNA damage and apoptosis in colon cancer
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Developmental regulation of the cell cycle; DNA replication; Drosophila as a cancer model
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Bowden,
Timothy G., PhD
Chair, Cancer Biology GIDP, Professor; Cell Biology and Anatomy, Molecular and Cellular Biology, Pharmacology and Toxicology, Radiation Oncology
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Molecular mechanisms of physical and chemical carcinogenesis; cellular oncogene activation and differential gene expression during tumor progression
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Role of oxidative stress in the mechanism of apoptosis
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Metabolism and biological functions of carotenoids
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Aging and cancer; role of tumor suppressor genes in cellular senescence and cellular response to oxidants
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Cress,
Anne E., PhD
Professor, Molecular and Cellular Biology, Biochemistry and Molecular Biophysics
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Professor, Cell Biology and Anatomy, Molecular and Cellular Biology
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Toxicology systems and mechanisms of action of cytotoxic anticancer agents; the pharmacology of cancer chemopreventive agents
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TGFB in T-cell homeostasis and tolerance
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Membrane trafficking in C. elegans
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Cancer epigenetics and epigenomics
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Biology of preneoplastic lesions
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Signaling pathways influencing growth and apoptosis in carcinogenesis; polyamine metabolism
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Identification of the molecular components and signaling mechanisms that regulate cytoskeletal protein interactions during striated muscle development
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Natural products and medicinal chemistry including isolation, characterization and partial synthesis of anticancer agents and their mechanisms of action; chemistry of the anticancer drug, Paclitaxel (Taxol®)
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Hall,
Jennifer, PhD
Associate Professor, Molecular and Cellular Biology, Biochemistry and Molecular Biophysics
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Mechanism of DNA replication, mutagenesis, repair and recombination in mammalian cells and animal viruses
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Molecular mechanisms of angiogenesis and prostate carcinoma epithelial-mesenchymal transformation
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Discovery and development of novel anticancer drugs; telomeres; telomerase; transcriptional control; topoisomerases as drug targets
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Study of molecular changes in gastrointestinal tract leading to malignancy for the purpose of identification of molecular markers for detection or prevention of gastrointestinal cancer
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Optimizing molecular and cellular responses to UV radiation in skin; inhibition of advanced glycation end-products; DNA damage and repair
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Molecular mechanisms involved in maintenance of genomic intensity
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Regulation and mechanisms of action of dendritic cells in inducing antitumor immunity; chaperone proteins in tumor immunology
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Cancer prevention and control; mechanisms of regulating sialyltransferase genes in colorectal cancer and metastasis; fibroblast biology
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signaling mechanisms involved in the regulation of apoptosis, radiation-induced DNA damage, secondary side-effects of cancer therapy that diminish patient quality of life
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Little,
John W., PhD
Professor, Biochemistry and Molecular Biophysics, Molecular and Cellular Biology
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Mechanisms of gene regulation; biochemistry of SOS response in E. coli, behavior and evolution of gene regulatory circuits
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Design and development of novel drugs to target oncogenic proteins
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Dietary Hetrocyclic Amines; Genetic Susceptibility; and Risk of Colorectal Cancer; Four Corners Breast Cancer Study; Colon Cancer Prevention Program Project; Arizona Family Registry for Colorectal Cancer Studies
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Cancer genetics, colon cancer chemoprevention; tumor suppressor genes; functional analysis of p53; role of bile acids in colon carcinogenesis
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Regulation of PTEN activity in cancer cells; Novel inhibitors of Akt as anticancer drugs
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Molecular genetics of steroid-regulated gene expression
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X-ray crystallography of macromolecules
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Mount,
David W., PhD
Professor Molecular and Cellular Biology, Biochemistry and Molecular Biophysics
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Bioinformatics, sequence and genome analysis of plants and animals; informatics support for cancer research
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Prostate carcinogenesis. Extracellular matrix integrin interactions
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Molecular mechanisms of physical and chemical carcinogenesis; biochemical and molecular pharmacology of cancer chemopreventive drugs
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Parker,
Roy, PhD
Professor, Molecular and Cellular Biology, Biochemistry and Molecular Biophysics
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mRNA decay in yeast, emphasizing molecular genetics to understand both the mechanisms and regulation of mRNA turnover
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Cellular and molecular mechanisms in mammary function; gene expression in cell proliferation and differentiation
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Schmelz,
Monika, PhD
Research Assistant Professor, Pathology
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Stem cells within the human prostate gland
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Thompson,
Patricia, PhD
Assistant Professor, Pathology
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Biomarker identification and validation for disease risk assessment and early detection; discovery of protein markers in nipple aspirate fluid
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Control of cell division in the yeast Saccharomyces cerevisiae; use of genetic, physiological and molecular techniques to study how the cell delays entry into mitosis if chromosomes are damaged
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Membrane traffic: molecular characterization of the composition and biogenesis of endosomal compartments in polarized and non-polarized cells
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Development of novel molecular agents for skin cancer chemoprevention and chemotherapy
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Interaction of camptothecin anticancer drugs with DNA and topoisomerase I; Novel DNA quadruplex interacting compounds
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Nrf2/Keap1 signaling pathway
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